Brand
name : VIRAMUNE (Nevirapine)
Pronounced: VIE-ruh-mewn
Generic name: Nevirapine
Why is VIRAMUNE (Nevirapine) prescribed?
VIRAMUNE (Nevirapine) is prescribed for advanced cases of HIV. HIV--the human immunodeficiency
virus that causes AIDS--undermines the immune system over a period
of years, eventually leaving the body defenseless against infection.
VIRAMUNE (Nevirapine) is generally prescribed only after the immune system has declined
and infections have begun to appear. It is always taken with at least
one other HIV medication such as Retrovir or Videx. If taken alone,
it can cause the virus to become resistant. Even if used properly,
it may be effective for only a limited time.
Like other drugs for HIV, VIRAMUNE (Nevirapine) works by impairing the virus's
ability to multiply.
Most important fact about VIRAMUNE (Nevirapine) without a prescriptions
The most important side effect of VIRAMUNE (Nevirapine) is a rash which occasionally
becomes so serious as to be life-threatening. The rash strikes approximately
one in four patients, and becomes severe in about 2 percent. It usually
appears during the first 6 weeks of therapy and strikes women more
often than men. If you notice any signs of a rash, inform your doctor
immediately. If it becomes severe or is accompanied by fever, blisters,
mouth sores, red eyes, swelling, muscle or joint aches, or general
fatigue, stop taking the drug and call your doctor.
How should you take VIRAMUNE (Nevirapine)?
Be sure to take VIRAMUNE (Nevirapine) every day, exactly as prescribed. Increase
the dosage only when directed. To avoid development of resistance,
be careful to take your other HIV drugs as well.
If you are using the oral suspension, shake it gently before each
dose. Give it to the child with an oral dosing syringe or dosing cup.
After each dose, rinse the cup with water and give the rinse to the
child as well.
If you miss a dose...
Take it as soon as you remember. If it is almost time for the next
dose, skip the one you missed and go back to your regular schedule.
Do not double the dose.
Storage instructions...
Store tablets and oral suspension at room temperature in a tightly
closed bottle.
VIRAMUNE (Nevirapine) side effects
Side effects cannot be anticipated. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can determine
if it is safe for you to continue using VIRAMUNE (Nevirapine).
* Side effects may include:
Abdominal pain, allergic reactions (including hives, blisters, mouth sores,
or swollen mouth and throat), anemia, diarrhea, drowsiness, drug withdrawal,
fat redistribution, fatigue, fever, headache, joint pain, liver damage, muscle
aches, nausea, rash, tingling, vomiting
Why should VIRAMUNE (Nevirapine) not be prescribed?
If VIRAMUNE (Nevirapine) gives you an allergic reaction, you cannot use this drug.
You should also avoid VIRAMUNE (Nevirapine) if you have severe liver impairment.
Special warnings about VIRAMUNE (Nevirapine)
VIRAMUNE (Nevirapine) has been known to cause serious--even fatal--liver damage,
especially during the first 18 weeks of therapy. People with hepatitis
B or C and women with a CD4+ cell count above 250 are more likely to
develop this problem. Overall, women are at greater risk than men.
If you already have moderate liver impairment, use VIRAMUNE (Nevirapine) with caution,
if at all. Warning signs of liver damage include fatigue, a vaguely
ill feeling, poor appetite, nausea, yellowish skin or eyes, pale stools,
dark urine, and tenderness in the midriff. Check with your doctor immediately
if you develop these symptoms. If liver damage has occurred, you'll
have to permanently discontinue VIRAMUNE (Nevirapine) therapy.
You should know that HIV medications also cause a redistribution of
fat in some people, increasing the amount of fat found around the middle
and on the upper back, and reducing the amount of fat in the arms,
legs, and face.
Remember that VIRAMUNE (Nevirapine) does not completely eliminate HIV from the
body. The virus can still be passed to others during sex or through
blood contamination.
Though VIRAMUNE (Nevirapine) can slow the progress of HIV, it is not a cure. HIV-related
infections remain a danger, so frequent check-ups and tests are still
advisable.
Possible food and drug interactions when taking VIRAMUNE (Nevirapine)
If VIRAMUNE (Nevirapine) is taken with certain other drugs, the effects of either
could be increased, decreased, or altered. It is especially important
to check with your doctor before combining VIRAMUNE (Nevirapine) with the following:
Clarithromycin (Biaxin)
Efavirenz (Sustiva)
Fluconazole (Diflucan)
Indinavir (Crixivan)
Ketoconazole (Nizoral)
Lopinavir/Ritonavir (Kaletra)
Methadone (Dolophine)
Nelfinavir (Viracept)
Rifabutin (Mycobutin)
Rifampin (Rifadin, Rimactane)
St. John's wort
Saquinavir (Fortovase)
Zidovudine (Retrovir)
VIRAMUNE (Nevirapine) may interfere with birth control pills and other hormonal
contraceptives. Do not use this form of contraception during VIRAMUNE (Nevirapine)
therapy.Also, it's important to talk to your doctor before combining
VIRAMUNE (Nevirapine) with any of the following:Antiarrhythmic heart medications
such as disopyramide (Norpace)
Anticonvulsant (seizure) medications such as carbamazepine (Tegretol),
clonazepam (Klonopin)
Antifungal medications such as itraconazole (Sporanox)
Blood-thinning medications such as warfarin (Coumadin)
Calcium channel blocker (angina) medications such as diltiazem (Cardizem),
nifedipine (Procardia), verapamil (Calan)
Cancer chemotherapy medications such as cyclophosphamide (Cytoxan)
Immunosuppressant medications such as cyclosporine (Sandimmune, Neoral)
Migraine medications such as ergotamine (Cafergot)
Opiate agonists (narcotic) pain medications such as fentanyl (Duragesic)
Special information if you are pregnant or breastfeeding
If you are pregnant you may be at a higher risk of developing serious--even
fatal--liver damage while taking VIRAMUNE (Nevirapine). If you are pregnant or plan
to become pregnant, notify your doctor immediately.
Avoid breastfeeding. HIV can be passed to a nursing infant through
breast milk.
Recommended dosage for VIRAMUNE (Nevirapine)
ADULTS
Overdosage
Any medication taken in excess can have serious consequences. If you
suspect an overdose, seek medical attention immediately.
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